Medscape

Does folic acid reduce methotrexate efficacy?

Cincinnati, OH - A new post hoc analysis of two randomized controlled studies suggests that folic acid diminishes the efficacy of methotrexate in the treatment of rheumatoid arthritis [ 1]. "The ...
Medscape

Experts debate folic-acid supplementation during methotrexate for RA

Manna and colleagues point out that there are currently no guidelines available outlining doses and timing of use. They write, "In our opinion, low doses of methotrexate without concomitant folate ...
News Medical

Supplementary folic acid associated with higher risk of COVID-19 diagnosis and mortality

In a recent study published in the journal BMJ Open, researchers investigated the impact of folic acid supplements and methotrexate, in combination or individually, on disease severity and mortality ...
News Medical

Study suggests folic acid supplementation linked to increased risk for COVID-19 diagnosis

In a recent study posted to the medRxiv* preprint server, researchers evaluated if folic acid or methotrexate use impacts the risk of coronavirus disease 2019 (COVID-19) diagnosis or associated ...
ascopubs.org

Association of genetic polymorphisms in the folate pathway with efficacy and toxicity of methotrexate in pediatric osteosarcoma.

Multicenter phase I/II trial of topotecan (T) and ifosfamide (I) combination as second-line therapy for pediatric solid cancer: Phase II results. This is an ASCO Meeting Abstract from the 2013 ASCO ...
ascopubs.org

Low-Risk Persistent Gestational Trophoblastic Disease: Outcome After Initial Treatment With Low-Dose Methotrexate and Folinic Acid From 1992 to 2000

Randomized Trial of Cisplatin and Ifosfamide With or Without Bleomycin in Squamous Carcinoma of the Cervix: A Gynecologic Oncology Group Study PURPOSE: We have simplified the treatment of gestational ...