A novel, investigational NaV1.8 sodium channel blocker known as VX-548 reduced acute pain after abdominoplasty or bunionectomy at the highest dose, but not at lower doses, two phase II trials showed.

Sodium channels — which transmit sensory information from neurons to the central nervous system — are logical targets for pain treatment. Nonselective sodium channel blockers can reduce pain, but they ...

Skeletal muscle channelopathies comprise a group of inherited disorders arising from mutations in ion channel genes that regulate muscle fibre excitability. Central to many of these conditions is ...